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The FDA of the United States reviewed the research on cannabis in the past 50 years, and re-examined and evaluated the future research on cannabis derivatives and CBD.

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The FDA of the United States reviewed the research on cannabis in the past 50 years, and re-examined and evaluated the future research on cannabis derivatives and CBD.

2023-12-01

Since the federal government listed cannabis as a Class I controlled drug, the US Food and Drug Administration (FDA) has been evaluating the applications of researchers seeking to develop therapeutic drugs from cannabis. In two newly published documents, the agency reviewed the research on cannabis drugs for more than half a century and put forward its own views on the future prospects of drug development.

This includes studying more extensive methods of smoking marijuana, such as eating marijuana, and investigating other ingredients such as cannabinoids and terpenes that are less well known.

In a blog post and an article in Medical Exploration magazine, FDA officials said that in the past 50 years, the FDA has evaluated more than 800 research new drug applications (INDs) involving cannabis and cannabis derivatives (CCDPs). During this period, the factors of cannabis product formation, cultural views and legal environment have undergone profound changes-all of which have been felt by FDA.

The author said that with more and more states legalizing marijuana for medical and adult use, the application of marijuana began to trickle down shortly after the passage of the Federal Controlled Substances Act (CSA) in 1970, and it has become a common practice in recent years. For example, in the past decade alone, the number of applications for cannabis-related drugs has been "almost the same" as the sum of the past 40 years. At present, the agency is actively considering more than 150 cannabis-related drugs and related synthetic drugs.

With the change of the times, FDA has strengthened its guidance to potential cannabis researchers and pharmaceutical manufacturers. In 2016, the agency issued a guidance document on the development of botanical drugs. Earlier this year, the agency issued a separate guidance document outlining cannabis and its unique considerations. 

"FDA continues to support the strong scientific research needed to develop new drugs from cannabis," the agency's author wrote in the article Exploration of Medicine, "and is committed to supporting the development of these new drugs through IND and drug approval procedures."

 
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